Various researchers are currently studying the impact of L-methylfolate on depression.
In one study where two parallel investigations were conducted, the researchers found that when 15 mg/day of L-methylfolate was given to patients, there was a significant improvement in the depressive symptoms of patients who received L-methylfolate compared to those who received a placebo.
These parallel investigations support that when given in the proper dosage, L-methylfolate may improve depression symptoms. In particular, patients who have experienced minimal improvement with antidepressants, have folate deficiencies, or have risk factors for inflammation may benefit the most from adding L-methylfolate to their treatment plan.
Additional studies have shown that the supplemental use of L-methyfolate can help improve outcomes in individuals with treatment-resistant depression. Patients with MDD who used L-methylfolate alongside another medication for depression reported significant improvement in their functioning in social situations, at home, and at work.
Although the use of L-methylfolate to assist with reducing depression symptoms needs additional study, the results so far are promising.